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《医学前沿(英文)》 2017年 第11卷 第1期 页码 20-31 doi: 10.1007/s11684-016-0493-4
To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.
关键词: gastrointestinal fluid gastric carcinoma biomarker diagnosis prognosis gastrectomy adverse events
A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 108-111 doi: 10.1007/s11684-014-0344-0
Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.
关键词: gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 317-321 doi: 10.1007/s11684-012-0203-9
In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumors (GISTs) after surgical resection, we collected clinical records of 80 patients with malignant GISTs. Tumor location, size, mitotic index, necrosis were compared with the prognosis of malignant GISTs by Kaplan-Meier method and log-rank test. After a median follow-up of 844 days (52–2 145), we found that as National Institutes of Health suggested, tumors with intermediate risk had more favorable prognosis than that with high risk. Their 3-year survival rate were 65.3% and 41.3%, respectively (P<0.001). Moreover, tumor size and mitotic index were associated with free survival. The 3-year survival rate for patients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively (P = 0.002), Tumors with mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5/50 HPF (67.1% versus 40.7%, P = 0.005). The presence of necrosis was directly related to the malignant behavior. The 3-year survival rate for presence and absence necrosis were 50.8% and 64.8% (P = 0.008). From the present study, we can conclude that besides tumors size and mitotic index, tumor location and necrosis also influence on the long-term survival of patient with malignant GISTs after surgical resection.
Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status
Chenfei Zhou, Jun Zhang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 12-23 doi: 10.1007/s11684-019-0685-9
Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients’ outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.
关键词: gastrointestinal cancer immune checkpoint inhibitor combination therapy
Gastrointestinal damage caused by swallowing multiple magnets
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 280-287 doi: 10.1007/s11684-012-0207-5
Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles published from June 1987 to October 2010 in Google, Medline, ISI Web of Knowledge Ovid, CNKI, Korea Med and library document delivery, using search terms “magnet ingestion, ” “fistula, ” and “perforation. ” A total of 149 patients with ingestion of magnetic foreign bodies from 20 countries and areas were identified. 22 of them were companioned with neurological and psychiatric disorders. Swallowing magnets occurred throughout childhood and adolescent, mostly ranging 2 to 4 years in age. Various gastrointestinal damages such as necrosis and intestinal perforation or fistula were encountered. Damage from swallowing multiple magnets carries a significant risk of morbidity and even mortality throughout childhood to adolescent worldwide. Older children and adults with neurological and psychiatric problems may be at high risk for such accidents. Early intervention is crucial.
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
《医学前沿(英文)》 2008年 第2卷 第1期 页码 87-94 doi: 10.1007/s11684-008-0016-z
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 101-111 doi: 10.1007/s11684-019-0698-4
关键词: mismatch repair protein deficiency (MMR-D) microsatellite instability (MSI) short tandem repeats (STR) gastrointestinal tumor hypermutability
Review of the LNG intermediate fluid vaporizer and its heat transfer characteristics
《能源前沿(英文)》 2022年 第16卷 第3期 页码 429-444 doi: 10.1007/s11708-021-0747-y
关键词: intermediate fluid vaporizer design of structure and intermediate fluid condensation heat transfer
Review of fluid and control technology of hydraulic wind turbines
Maolin CAI, Yixuan WANG, Zongxia JIAO, Yan SHI
《机械工程前沿(英文)》 2017年 第12卷 第3期 页码 312-320 doi: 10.1007/s11465-017-0433-2
This study examines the development of the fluid and control technology of hydraulic wind turbines. The current state of hydraulic wind turbines as a new technology is described, and its basic fluid model and typical control method are expounded by comparing various study results. Finally, the advantages of hydraulic wind turbines are enumerated. Hydraulic wind turbines are expected to become the main development direction of wind turbines.
关键词: wind turbine hydraulic system fluid model control technology
Computational fluid dynamics simulation of aerosol transport and deposition
Yingjie TANG, Bing GUO
《环境科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 362-377 doi: 10.1007/s11783-011-0365-8
关键词: computational fluid dynamics (CFD) aerosol transport deposition
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1149-1163 doi: 10.1007/s11705-021-2096-0
关键词: carbon dioxide photoreduction computational fluid dynamic simulation kinetic model Langmuir adsorption
Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract
Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 40-44 doi: 10.1007/s11465-011-0204-4
Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinal tract. This method offers a less-invasive alternative to traditional endoscopy by eliminating uncomfortable procedures of the traditional endoscopy. Moreover, it provides the opportunity for exploring inaccessible areas of the small intestine. Current capsule endoscopes, however, move by peristalsis and are not capable of detailed and on-demand inspection of desired locations. Here, we propose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal disorders. The vision systems in these capsules are equipped with mechanical actuators to adjust the position of the camera. This may help to cover larger areas of the digestive tract and investigate desired locations. The preliminary experimental results showed that the developed platform could successfully communicate with the external control unit via human body and adjust the position of camera to limited degrees.
关键词: wireless capsule endoscopy ingestible medical device in-body medical device miniature actuator medical robot medical imaging
Wind-induced vibration control of Hefei TV tower with fluid viscous damper
Zhiqiang ZHANG , Aiqun LI , Jianping HE , Jianlei WANG ,
《结构与土木工程前沿(英文)》 2009年 第3卷 第3期 页码 249-254 doi: 10.1007/s11709-009-0038-x
关键词: high-rise structure wind-induced response fluid viscous damper vibration control
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1525-8
• Effect of gastric fluid on EDCs adsorption-desorption to microplastics was evaluated.
关键词: Microplastics Gastric fluid Endocrine-disrupting chemicals Adsorption Desorption
《结构与土木工程前沿(英文)》 2023年 第17卷 第3期 页码 477-502 doi: 10.1007/s11709-023-0918-5
关键词: static bending free and forced vibrations nonlocal theory isogeometric analysis fluid-infiltrated porous nanoplates
标题 作者 时间 类型 操作
Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination
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期刊论文
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
null
期刊论文
Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status
Chenfei Zhou, Jun Zhang
期刊论文
Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
期刊论文
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
期刊论文
Review of fluid and control technology of hydraulic wind turbines
Maolin CAI, Yixuan WANG, Zongxia JIAO, Yan SHI
期刊论文
Computational fluid dynamics simulation of aerosol transport and deposition
Yingjie TANG, Bing GUO
期刊论文
Investigation of carbon dioxide photoreduction process in a laboratory-scale photoreactor by computational fluid
期刊论文
Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract
Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE
期刊论文
Wind-induced vibration control of Hefei TV tower with fluid viscous damper
Zhiqiang ZHANG , Aiqun LI , Jianping HE , Jianlei WANG ,
期刊论文
Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics
期刊论文